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The anticoagulant Plavix, Sanofi's flagship drug, loses its patent on Thursday the United States. Although long-expected, this is a difficult stage for the championship tricolor pharmacy. The arrival of generics is usually depressing sales of an original drug by 80% within months. However, in 2011, sales of Plavix in the United States accounted for 4.8 billion euros. In accounting terms, the decline in sales will have no impact on the accounts of the champion tricolor because the marketing of its flagship product is provided by the U.S. laboratory BMS.

The benefit of Sanofi will, however, heavily impacted. In 2012, the group's net profit will suffer an impact of 1.4 billion euros, due to the loss of U.S. patents on two products, Aprovel / Avapro in March and especially Plavix May 17, announced Chris Viehbacher, CEO of Sanofi in February.

Plavix had already lost its patent protection in Europe. But its total turnover in 2011 reached 7 billion euros. This made so ephemeral, without doubt, the top-selling drug in the world, after the cholesterol-lowering Lipitor, sold by Pfizer, has lost its patent protection last November.

Clopidogrel, the active ingredient used for generic for Plavix and marketed by the French lab is fully produced Sisteron (04). However, the laboratory will manufacture other chemical molecules, which means that 500 jobs are not threatened by the loss of U.S. patent for Plavix, Sanofi sure.  

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Next times the need arises for a online cash advance, whether it's for car repairs, to pay bills, or simply to get away for a vacation go to a pay day lender for your cash.

 

Since Friday, the plant Fralib is occupied by its employees. A situation that is denounced by the president of Unilever France, Bruno Witvoët. "This is unacceptable in a constitutional state, says in an interview in Paris-Today-in-France. Such a coup with hooded individuals armed with baseball bats and batons, it is not of union action, it's a commando! ". The boss of Unilever France claiming the expulsion "immediate and prompt action with law enforcement" employees, has also filed a complaint for "physical threats" from the police. "From fabrications," Olivier replied Leberquier, CGT union. According to the police of Aubagne, intervened at the scene, there would have been no collision.

"Holland must keep its promises"

"Closing a plant is always a very difficult decision, Bruno recognizes Witvoët. But in some cases – including tea bags – we have overcapacity. This is justified in stopping this site ". He said Unilever has taken responsibility in the case of employees of Fralib, accepting "to add additional resources for the revitalization of the local employment" as required by justice. "Funds for creating new jobs has increased from 1 to 1.5 million euros" and "each dismissed employee is entitled to an internal transfer, pay the same conditions, in one of six other plants in France , "he said.

This new twist, the 592nd day of the conflict comes as 80 of the 103 employees still struggle, of 182 initially received their letter of dismissal. At the same time, a moving company came to do a quote on the site, and management proposed the CGT to move out of its local business, or in organizing the escorted access, for reasons of safety concerns, dismantling machinery. A scenario rejected by the union, which wants to keep the tool working on site to implement an alternative plan of recovery of activity.

Given this situation, unions are demanding the intervention of Francois Hollande. During the presidential campaign, President-elect said: "Nothing is done, nothing is guaranteed and if victory comes, I will also be at your side, President of the French Republic, to get your site live, had he launched at a meeting of employees Fralib in Paris in February. "The company is now under the control of the CGT and the Netherlands should keep its promises. His election is a ray of hope, "says Olivier Leberquier. The standoff between employees Fralib and its direction is far from over.

Presidential in major cities Paris | Leeds | Lyons | Toulouse | Leeds | Sheffield | Liverpool | Bordeaux | Lille

1) Analyze your current complementary health

If you are employed, you get maybe a complementary health, proposed by employeur.Si after your examination you find it unsuitable for your needs do not hesitate to purchase one additional complementary health ……. . 2) Identify your needs and your budget

Before you start, ask yourself what kind of care you need it most (dentist, glasses, general practice) and identify your medical habits. Indeed, you do not need the same insurance company if you see doctors contracted to 70% reimbursed by Social Security or doctors to free fees.

3) Find and compare

Take time to learn about the different types of contracts. Please note that refunds of medical expenses range from 100% rate of Social Security, up to 300% thereof.

4) Seek advice from a health insurance broker

The health insurance broker acts as an intermediary between you and the insurer. It will help you in your choices, while allowing you to access the best rates and insurance that best suits your needs.

5) Pay attention to waiting periods

The waiting time is practiced by some insurance companies after your subscription. During this period, some services are not covered by the insurer. Do not hesitate to negotiate for the minimize, or even to choose the practitioner does not mutual online pay day loans.

6) Be wary of health questionnaires

The questionnaires are sometimes used by health insurers to overcharge or exclude one or more benefits considered too "risky". Prefer mutuals who do not use.

7) Wear an eye on the guarantees Dental-Optical-Hospitalization

These guarantees are often three parts of the first requirements of the insured, and are at home that we observe the largest price changes and benefits based on mutual.

8) Look care not covered by Social Security

Indeed, many mutual support services not reimbursed by Social Security. Thus, vaccines, consult a psychologist or treatments to stop smoking can sometimes be covered by complementary health.

9) Prefer Refunds indicated clearly

Some insurance companies are unclear on their actual repayment rate. Always prefer mutual indicating these black and white.  

10) Evolve your contract

Regularly take the time to redefine your budget, your needs and expectations of health, and give yourself the opportunity to change your contract. It will always be easier if you go through an insurance broker.

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Elior not lose your appetite. Sales of the French group, number three European restaurants, jumped 10.4% during the year ended in late September, to 4.2 billion euros. The increase in trading profit was faster: + 14% to 254 million.

Bulimic, Elior completed in March fourteenth acquisition since leaving the Stock Exchange in 2006, swallowing Ansamble, based in Vannes, for an undisclosed sum. The group becomes co-leader, elbow to elbow with Sodexo, the catering in France, where he made last year 56% of its activity. Already number one in Spain, until its second market, Elior will become the leader in Italy with the acquisition of Gemeaz, which allows him to double its turnover. "We now have our three leading markets in Europe, and we can enter a new stage of our development," says Robert Zolade, chairman of the supervisory board and a 25% shareholder group.

The priority is to develop the catering concession (in airports, train stations, highways or parks …), which represented the third year of activity. Elior has won contracts Autogrill face of the Motorway of Poitou-Charentes (A10), one of the largest in France, and the Gare de Lyon in Paris. There he intends to set up signs and Costa Coffee Red Hippo, who will begin their free development. "We are the only operator present in both the catering and concession. We can install in the canteens of corners Paul, Exki and Bert's, "said Gilles Petit, the director general.

The sale of 75% held by Charterhouse easier

This is especially the United States that the group intends to develop its activity in concession. He has just picked up the management of its U.S. subsidiary Areas (600 million euros of turnover). "We now have a truly global hub catering concessions which will represent half of our business," says Gilles Petit, determined to win market share.

Elior is not abandoned, however, catering, more resistant to shocks in the economy. "In France we have a development potential in the areas of administration and education," says Robert Zolade. After winning the tender to manage the restoration of central Fleury-Merogis, Elior holds 20% market share of prisons in France.

For the current fiscal year, the group seeks organic growth of its business catering from 2 to 2.3%. For catering concession, "everything will be played this summer," says Gilles Petit.

Moreover, Elior has renegotiated the repayment of its debt (1.8 billion euros to 31 September), pushing 2013 to June 2017 the next major milestone. "We have no constraint in the implementation of our strategic plan," says Robert Zolade. This will allow the transition to English investment fund Charterhouse, a shareholder since 2006, to more easily find a possible buyer for its 75%.

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A rating agency on three, Standard & Poor's, has already withdrawn its prestigious Aaa to France. One of its competitors, Moody's, could soon follow, warned the Socialist candidate for president Francois Hollande. In the days following the presidential election.

Moody's placed under the supervision of the French debt rating earlier this year, he said in an interview with Journal du Dimanche. It "will make a decision on May 12, he argued. It will not be a consequence of the May 6 vote of the French. I warn, already, for our fellow citizens that there is no confusion (…) For now, I ask in any case to be assessed by the French and not by markets. "  

How the candidate can know the date on which the decision will fall on Moody's France? Rating agencies maintain absolute secrecy about the content of their deliberations and their timing, until the publication of their decision. To predict the date of May 12, the candidate is based on the deadline set by the agency between his warning to the country concerned and the actual announcement.

Moody's placed the rating a negative outlook on Feb. 14. It can give its verdict – probably too negative for AAA French – in May. However, it would have a year to decide. "She may wait to see what measures are being implemented by the future president, for example until fall, when the budget for 2013 will be presented," qualifies Norbert Gaillard, specialist rating agencies.  

Clearing the ground

Francois Hollande tried to clear the ground, should he be elected, and while his main opponent, Nicolas Sarkozy, waved the threat of an attack against France markets where Socialist victory. Today, has defended the PS candidate, turbulence affecting Spain and Italy but not France. "It is particularly irresponsible for the incumbent to use the threat of speculative movements to persuade voters to abandon the alternation," he pleaded.

The first week of the next president, whoever he is, ahead eventful. First Moody's should actually decide before May 15 the fate of Aaa it attributed to France so far. Then the Commission will publish its opinion on the stability program of France. This document, sent to Brussels last week, details how the government intends to restore the balance of public finances by 2016. Problem: it takes into account neither the promises of the outgoing president, nor those of his socialist opponent.

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The revolution of the gas in the U.S. is running. By midweek, the price of natural gas in New York reached a record low, at less than $ 2 million BTUs (British thermal unit) – the international measure equivalent to 28 m3 of gas. Not since ten years ago to find such a price. The particularly mild climate this winter and falling demand support this decline in prices, but they do not explain everything.

"There are six to seven years, the magnitude of the reserves of shale gas across the Atlantic was largely unknown. Today, operators have mastered better and better their production and extract larger quantities with less drilling, exposes Olivier Rech, cofounder of investment consultant Energy Funds Advisors. Meanwhile, even when they go out of oil, they get associated gas. Under these conditions, the abundance of supply weighs on prices. "

This new situation gives ideas to operators. GDF Suez for example, could invest in the downstream side of the Atlantic, that is to say to provide gas, liquefy it and send it to other markets. However, an investment directly in the production in the U.S. is not on the agenda, warned Jean-Marie Dauger, Executive Vice President of the GDF Suez, in charge of Global Gas and LNG (LNG).

Concentration for

In general, the French group makes it clear that a gas supply in North America is based primarily on a prospective scenario. Understood: the market test medium-term guide strategic choices.

In Asia, Mitsubishi Corporation is also exploring several alternatives. After acquiring 40% in February from a field of shale gas in Canada Encana, the Japanese company is considering a giant project (€ 10 billion investment about) LNG production in British Columbia, the west. Several partners are in discussions, including Shell and Korean Korea Gas – who buys every year 30 million tons of LNG.

This situation of depressed gas prices in North America Will it continue permanently? "Above all, this situation is abnormal. In most regions in the U.S., gas prices are now below production costs. Under these conditions, many are fragile and gas operators in the two to three years ahead, there could be a phenomenon of concentration, says Olivier Rech. The revolution of the gas in the United States will therefore damage among companies.

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SFR on Monday launched an aggressive promotional campaign. Its triple play offer, including the high speed internet, HD television and unlimited fixed telephony is available from 14.90 euros per month for a year, instead of 31.90 euros. The price is EUR 19.90 instead of 37.90 euros, with unlimited mobile telephony. SFR mobile subscribers receive an additional 5 euros, bringing access to triple play 9.90 or 14.90 euros a month, according to the chosen tender. These rates also apply for a subscription fiber.

The promotion of SFR, which formalized the replacement of its CEO last week, is limited to first 5000 subscribers and will end this Friday. It recalls the operations performed by Free site in partnership with the Sales-privees.com, who proposed in 2010 a triple play to 10 euros per month, then to 1.99 euro next year. It also places the price of the subscription neufbox at Alice's, offer low cost Free. This package, just highlighted to Free, includes the Internet, fixed telephony and television from 11.98 euros per month.

The offer is part of SFR in a particular context, however, since the arrival of Free in the mobile sector. In 2011, its competitor has maintained a very high margin of 39.3%, thanks to its activity in ADSL, which allowed him to expand into the mobile. Free on the fixed address could be a way to respond to its new mobile offerings. Meanwhile, SFR also seeks to support its recruitment in the fixed. In 2011, its subscriber base grew by only 3.2% (5 million customers), two times less than the growth of Free (4.8 million subscribers).

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Unicredit closed Tuesday, piteously, the ball of the annual results of European banks. As expected, the first Italian establishment has suffered a massive loss of over € 9 billion. After years of too-rapid expansion, the bank decided to move his record to steel wool, to "have no surprises in the future," according to Director General, Federico Ghizzoni. This momentary dip of Unicredit in the shallows of the European ranking – the institution displays the worst performance of the sector just after Dexia – illustrates the new hierarchy of banks.

2011 will remain above all marked by the sharp inflection, from the summer, the crisis in the euro area. Institutions of the countries attacked – Italy, Spain, Portugal, Ireland and Greece of course – all bear the scars. They charged a double shock: degradation of their national sovereign debt and recession in their economies against the backdrop of austerity. In this grim context, the first two Spanish banks, Santander and BBVA, have their own in the game With their exposure to emerging markets, they show profits down "only" 35% to 5.4 billion and 3 billion euros, despite a national real estate market devastated.

The challenge of regulation

Second great lesson of the banking hierarchy 2011: the resistance of so-called universal institutions, which rely on local networks, possibly spread over several countries, and financing activities and investment. The success of British giant HSBC and Standard Chartered, whose results have respectively increased by 28% and 12% in one year, illustrates this situation. The resilience of the French BNP Paribas, proud of its profit more than 6 billion euros and its three major European networks, is another variation. Conversely, the Swiss UBS and Credit Suisse, highly dependent on performance of their teams of traders and bankers, driving out of this year huge market turmoil. Their profits were down 44% and 62%.

The challenge of regulation

Deutsche Bank is a notable exception: despite its similar profile, the champion Frankfurt has completed a very successful year. Up 86% year on year, the result exceeds 4 billion euros. Market valuations of the front runners as broadly these capabilities beneficiaries. HSBC leads the pack with a value of 122 billion euros, while Santander, BNP Paribas and Deutsche Bank weigh respectively 58, 45 and 36 billion in stock.

If Dexia puts the finishing touch of color to the landscape reshaped by the financial crisis. The little French-Belgian bank, run contrary to common sense for years, has lost 11.6 billion euros in 2011. A disaster that financial regulators do not want to hear. To guard against this, they launched a vast banks race to the recapitalization, which will mobilize the entire sector in 2012.

 

Corsairfly becomes … Corsair International. "A change but not revolution," agrees Pascal de Izaguirre, CEO of the airline of TUI. The leaders of the giant European Tourism chose a facelift to revive the company acquired by Nouvelles Frontieres in 1990 when Jacques Maillot was at the controls. At the time it was called Corse Air International

.

Everything has changed since: the German TUI shareholder meeting in France Marmara Tourinter, New Frontiers and renamed the airline Corsairfly stripped a quarter of its workforce … He has invested hundreds of millions of euros to transform the old a charter company whose regular cabs devices have been fully refurbished mid-2013 with a budget of 36 million euros.

Financially, the subsidiary of TUI could not afford a complete change of name: "Rather than spend a fortune to switch brands, it is better to devote resources to what the customer appreciates the ground or on board" , says Pascal de Izaguirre CEO of Corsair International.  

Erase the image and low-cost charter

A budget of 2.5 million euros will be spent on change of visual identity (logo creation, uniforms, aircraft painting). The first plane scratched white and blue logo of the retro graphics will be delivered in July. The other six, including two new A 330 will follow until mid-April 2013.

But another reason is given by the CEO of Corsairfly to explain the lack of boldness in the choice of name: "The Corsair brand is extremely well known. Hostesses and stewards are known to be friendly and smiling. "The old company Nouvelles Frontieres is certainly an image associated with cheap, but also a Spartan comfort payday loans direct lenders.

"Corsair will celebrate its 31 anniversary this year, little known company such longevity, defends Pascal de Izaguirre. Many have disappeared, new arrivals are. We remove the "fly" but also the name of "smiley" logo TUI, not to hide our group membership, but to erase anything that might suggest the charter or low cost. "…. ….

The team of TUI wants to play the card of elegance, high quality services, while remaining competitive on price. The number of seats "open sea" (comparable to a business class) increases from 24 to 36 in the Boeing 747 and 18 to 26 in the A 330. "We have invested heavily in-flight services, airport lounges to Orly, Pointe-à-Pitre and Fort de France, and soon the meeting …"

New destinations

The relaunch of the company scheduled two years ago falls to one of the worst periods through which the world of air: the rates are low while the cost of jet fuel has stabilized at a very high level that weakens companies.

"This does not undermine our vision and direction, says the CEO of TUI France. We are currently addressing the structural problems of the company and it is not challenged by economic factors. TUI, our shareholder, has powerful resources. He made a choice that takes the long term. "

Corsair International will also review its destinations in September, the company will cease to serve Miami. Instead it will open a line to Punta Cana in the Dominican Republic, a destination that has grown 15% since the beginning of the year.

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